RxPlorer: Receptor/Ligand Diagramming Tool
This app aggregates data from public databases for ligand/receptor affinities and interactions.
The idea is to enable users to create their own versions of the familiar tables of medication-receptor affinities found in pharmacology textbooks and produce graphical representations. The available searches (i.e. receptors) focus on psychotropic medications and collates data from the databases below.
For example, you can search and visualise data that answers questions such as 'What is the affinity and antagonism/agonism profile on DA1 through DA5 receptors for Olanzapine and Haloperidol ?'
This app is only possible because of the generosity and efforts of:
The UNC PDSP Ki Database -- BL Roth, WK Kroeze, S Patel and E Lopez, The Multiplicity of Serotonin Receptors: Uselessly diverse molecules or an embarrasment of riches?, The Neuroscientist 6:252-262, 2000 and Netwatch, Science 28 January 2000; 287 (5453)
The IUPHAR-BPS Databases -- Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Sharman JL, Campo B, Cavanagh DR, Alexander SPH, Davenport AP, Spedding M, Davies JA; NC-IUPHAR. (2019) The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY. Nucl. Acids Res. pii: gkz951. doi: 10.1093/nar/gkz951
Both databases are freely available and for this current version, use the May 2020 versions.
In order to comply with the spirit and licensing of these publically-available databases, the code for this app is distributed under the Attribution-ShareAlike 3.0 Unported (CC BY-SA 3.0) licence. It was developed in R and Shiny
